ATG16L1 and ATG12 Gene Polymorphisms Are Involved in the Progression of Atrophic Gastritis

Helicobacter pylori (H. pylori) infection causes a progression to atrophic gastritis and results in gastric cancer. Cytotoxin-associated gene A (CagA), major virulence factor of H. pylori, is injected into epithelial cells using the type IV secretion system. On other hand, degrade CagA an autophagy system, which strictly regulated by autophagy-related (ATG) genes. This study aimed identify SNPs ATG5, ATG10, ATG12, ATG16L1 associated with mucosal atrophy (GMA). Here, two-hundred pylori-positive participants without cancer were included. The degree GMA was evaluated via pepsinogen method. Twenty-five located four candidate genes selected as tag SNPs. frequency each SNP between non-GMA group evaluated. rs6431655, rs6431659, rs4663136 rs26537 ATG12 independently GMA. Of these SNPs, G/G genotype rs6431659 has highest odd ratio (Odds = 3.835, 95% confidence intervals 1.337–1.005, p 0.008). Further functional analyses prospective larger sample size are required.